INNOVATION ACTA SRL

Forschungsprojekte

• Gene-edited T cells combating IgA Nephropathy. A blueprint approach for safe & efficient genome editing of T cells to sustainably combat several immune diseases and cancers related to B-cell pathology "There is an increasing prevalence of chronic diseases caused by undesired immune reactions (>10%) with high…
• An integrated approach to restore tolerance in autoimmune disease The TOLERATE training network aims at training DC’s to acquire the skills to develop different innovative str…
• FINE-TUNING T CELL NETWORKS OF EXHAUSTION BY SYNTHETIC SENSORS Cell and gene therapies offer a massive paradigm shift from current treatment options and hold the potential…
• PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES Osteoarthritis (OA) is the most common form of arthritis worldwide. Chronic low-grade inflammation in the art…
• Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases Cohesin is an evolutionarily conserved multi-protein complex that belongs to the structural maintenance of ch…
• GUIding multi-moDal thErapies against MRD by liquid biopsies - GUIDE.MRD Advancing personalized approaches in cancer therapy, aiding identification and adaptation of multi-modal trea…
• ADVANCED ANTIGEN-SPECIFIC DENDRITIC CELL-BASED THERAPY TO RE-ESTABLISH TOLERANCE IN IMMUNE-MEDIATED DISEASES Autoimmune diseases are currently treated with immunosuppressive and supportive therapies, which dampen infla…
• A training network on the design of precision therapeutics that target key glycan motifs implicated in cancer Glycoscience has gained such significant technological advances over the past decade, that it is now poised f…
• B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD Atherosclerosis is the major underlying condition of cardiovascular disease (CVD) and one the leading causes…
• GLYCOprotein N-glycosylation from non-life to eukaryotes: a Doctoral Network to expand the knowledge on a ubiquitous posttranslational modification of proteins The GLYCO-N training network aims at training Doctoral Candidates (DCs) to acquire the skills to develop diff…
• Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation Organ transplantation remains the only definitive treatment for end-stage heart, lung, liver or kidney diseas…
• Training for Organoids modelling Physiology and Pathology in the human gastrointestinal tract In the aging society, disease burden, such as degenerative diseases and cancer are rising while drug developm…