Genomik

Forschungsprojekte

• Compressed Indexes for Regular Languages with Applications to Computational Pan-genomics Sorting is, arguably, the most powerful algorithmic primitive when it comes to indexing data. At the same tim…
• Exploring the Holobiont concept through a Plant Evolutionary Experiment study The evolutionary processes underlying interactions between hosts and their associated microbes is a black box…
• EU-Africa Concerted Action on SAR-CoV-2 Virus Variant and Immunological Surveillance Despite of the successful advances achieved to date in the fight against the COVID-19 pandemic with the devel…
• Deciphering the genetic basis of chronic kidney disease towards prevention and personalized therapy Chronic Kidney Disease (CKD) is a public health challenge affecting millions globally. Patients have increase…
• Epigenetic and transcriptional basis of memory engram plasticity Neuroplasticity underlies learning and memory formation, which allows for accumulation of knowledge. There is…
• Exploring the Prokaryotic-Eukaryotic Conservation of Antiviral immunity: from bacterial immune systems to novel antiviral drugs Bacteria have evolved multiple lines of defense against their viruses, bacteriophages. Such weapons include r…
• Functional Measurements IN-THE-KIDNEY to Diagnose, Understand and Treat Renal Tubulopathies BACKGROUND | Renal tubulopathies are a large group of genetic disorders that disturb the function of the kidn…
• Deciphering cellular and viral determinants of lytic HSV-1 infection, latency and reactivation Herpes simplex virus 1 (HSV-1) is an important human pathogen which infects the majority of the world`s popul…
• Selection efficacy at intraspecific and interspecific scales: insights from haplo-diplontic plants Natural selection is a pillar of evssNatural selection is a pillar of evolutionary biology: it tends to fix b…
• Elucidating and targeting the mechanisms encoded in the genome of long-lived individuals to improve healthy ageing Advancing age is the major risk factor for many serious illnesses, including cancer, cardiovascular disease,…
• Mechanisms of proliferation-independent mutation DNA damage contributes to the ageing of tissues and causes mutations that drive cancer. However, the molecula…
• The basic principles of polyploidy in plants and animals Many eukaryotes have more than two sets of chromosomes due to whole-genome duplication (WGD) and are called p…