PeRsonalised treatmEnts and pain manaGEmeNt for rEpaiR of Aged bone Tissue wIth quantum mOlecular resoNance

REGENERATION aims to build a multidisciplinary research network bringing together complementary expertise in life sciences, bioengineering, medical-device development, computational modelling, artificial intelligence and Quantum Molecular Resonance (QMR) technologies. The project will develop reliable and sustainable in vitro models of healthy and aged bone tissue, treated with or without QMR, and will train a cohort of scientists and technologists in exploiting these models to increase knowledge on bone ageing, mechanobiology, response to physical stimulation and drug-related effects.

Bone ageing reduces the quality of life of elderly people and creates a significant social and economic burden. Ageing bones fail more easily when challenged mechanically or exposed to toxicants or pollutants, and they may respond differently to drugs and physical stimuli compared with healthy bone. To personalise therapies and enable better preventive care for the elderly, it is essential to develop reliable human-based in vitro models of aged bone tissue, reducing dependence on animal models that are costly, ethically sensitive and often unable to capture human-specific features.

REGENERATION will involve 10 active participants from 5 countries: Italy, Greece, Germany, Spain and Switzerland. The consortium brings together universities, research centres and private companies with complementary expertise in cell culture, scaffold optimisation, QMR-based stimulation, dynamic bioreactor culture, microvascularisation, immune-cell interactions, computational modelling, artificial intelligence, bioengineering design and exploitation of biomedical technologies.

The project activities will focus on the development and optimisation of scaffold-based 3D bone models, the use of QMR technology to stimulate and functionalise bone constructs, the integration of vascular and immune-system components to better reproduce relevant in vivo conditions, and the development of computational and data-driven models to support interpretation and optimisation of the experimental results. Dynamic culture systems and advanced culture-device solutions will be used to improve the reproducibility and physiological relevance of the models.

Through international, interdisciplinary and intersectoral staff exchanges, REGENERATION will generate new knowledge on the mechanisms of bone growth, regeneration and ageing, and on the effects of QMR stimuli on cell proliferation, differentiation and transfection. The project will strengthen long-term collaboration between academic and non-academic partners, improve research and innovation capacities across the consortium, and support the development of new tools, protocols and exploitable results in the fields of tissue engineering, regenerative medicine, in vitro testing and biomedical technology.