Mutationen in der meiotischen Rekombination

Projekt Mapping genetic suppression interaction networks in DNA break repair disorders DNA double-strand breaks (DSBs) occur frequently during a cell’s lifetime and constitute the most cytotoxic DNA lesion. DSBs comp… Beitrag ansehen

Projekt Nicht-kohäsive Rollen von Kohäsinen in Meiose Cohesin, Yeast Meiosis, Synaptonemal Complex, Axial Element, Loop Extrusion, Meiotic Recombination, Naturwissenschaften, Humanmed… Beitrag ansehen

Projekt Resistenzevolution bei soliden pädiatrischen Tumoren mit HRD Drug resistance, Cancer evolution, Genomics, Chromosomal instability, Paediatric cancer, Homologous recombination repair, Naturwi… Beitrag ansehen

Projekt Mechanisms of proliferation-independent mutation DNA damage contributes to the ageing of tissues and causes mutations that drive cancer. However, the molecular mechanisms underly… Beitrag ansehen

Projekt Reversing the advantage of cancers with Hypoxia and Homologous Recombination Defect (HRD) by using a pan-cancer, composite, lesions-specific biomarker Hypoxia-activated prodrugs (HAPs) are a great concept in particular in association therapies more efficient on well-oxygenated ce… Beitrag ansehen

Projekt Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases Cohesin is an evolutionarily conserved multi-protein complex that belongs to the structural maintenance of chromosomes protein fa… Beitrag ansehen

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