Diagnose Alzheimer’s disease with isotopes

During the course of the PRISTINE proposal we have developed the first high precision high sensitivity stable isotope measurements for a variety of vital elements, including Zn, and Cu . With these technical advances we realized that we could monitor stable isotopic changes within organisms that open up a new way to study metal homeostasis as well as a new ways of detection diagnosis for diseases, in particular the Alzheimer's disease.

In DAI, we will further explore make use of these unique technical advance to demonstrate the feasibility of using stable isotope geochemistry of metals to detect the early stages of the Alzheimer's disease. to reach this goal, we will combine our technical skills developed during PRISTINE with medical science to demonstrate this proof of concept and if succesful to file a patent. This would represent a unique way to apply isotope cosmochemistry to medical science fields.