Analysis of the volatile organic compounds emitted by extracellular vesicles for disease diagnosis

This project aims at investigating the potential of analysing the volatile organic compounds emitted by extracellular vesicles as an innovative approach for disease diagnostic. Extracellular vesicles will be isolated from different biological samples, such as cancer cells, serum, urine and seminal bull sperm. The volatile organic compounds emitted by the extracellular vesicles will be analysed employing several techniques, which will include gas chromatography coupled to mass spectrometry, vibrational spectroscopy and electronic nose systems. The results obtained in this project will ultimately allow assessing if the volatile organic compounds emitted by extracellular vesicles can provide additional information for disease diagnosis complementing the analysis of the biological samples from which they are extracted.