FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS

Forschungsprojekte

• RNA PROCESSING FOR ANTI-CANCER IMMUNOTHERAPY In the past five years, RNA therapeutics have witnessed a true revolution. Several RNA-based therapies have b…
• Contribution of Lipid Droplets to the pathogenesis and chemoresistance of Acute Myeloid Leukemia Acute Myeloid Leukemia (AML) results from the uncontrolled expansion of differentiation-defective hematopoiet…
• Identification and characterization of long non-coding RNAs as drivers of stemness in hematopoietic stem cells and leukemia. Hematopoietic stem cells (HSCs) are a unique population defined by their self-renewal capacity and the potent…
• Role of the SIRT7-NPM-c-Myc pathway in lung cancer Lung cancer is the second cause of death due to malignancy and diagnosed patients rarely survive beyond two y…
• Scaling Up secure Processing, Anonymization and generation of Health Data for EU cross border collaborative research and Innovation The overall goal of the SECURED project is to scale up multiparty computation, data anonymization and synthet…
• Next generation, off-the-shelf, non fratricide-directed, CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic leukemia R/R T-ALL remains a major clinical challenge. Despite improved survival rates thanks to intensive chemotherap…
• Elucidating the role of macroH2A1.2 histone variant as a metabolic sensor in the epigenetic regulation of leukaemia cell fate. The initiation and maintenance of leukaemia are often regulated through the interaction of epigenetic mechani…
• CD22/CD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia Anti-CD19 immunotherapies based on Bi-specific T-cell Engagers (BiTE) or chimeric antigen receptor (CAR)-expr…